谢努力,男,博士学位,讲师,湖南郴州人。2014年本科毕业于湖南大学,2019年博士毕业于湖南大学化学化工学院,师从黄晋教授和王柯敏教授。2017-2019期间受国家留学基金委的资助公派赴美国密歇根大学安娜堡分校交流2年,师从国际著名材料学家Nicholas Kotov教授。回国后进入进入上海交通大学樊春海院士团队开展博士后研究。曾获国家奖学金,湖南大学“优秀研究生”,上海市“超级博士后”等荣誉称号。
研究领域:
1.核酸-金属纳米材料的药物递送研究;
2.核酸纳米技术在疾病诊疗中的应用;
截止目前,在Nature(二作)、JACS、Angew. Chem. Int. Ed.、ACS Nano、Chem. Sci.、Anal. Chem.、Chem. Commun.等国际知名期刊发表论文数十篇,其中一作论文10余篇, 论文总引次数达 1700次以上。
主要论文:
1. Hui Lv, Nuli Xie, Mingqiang Li, Mingkai Dong, Jiang Li, Xiaolei Zuo, Haibo Chen, Fei Wang*, Chunhai Fan*. Large-scale reconfigurable DNA-based logic gate for complex DNA computing. Nature 2023, 622, 292-300. (SCI一区)
2. Zhenxiang Liu#, Nuli Xie#, Juan Li, Xiaoxiao Fu, Kemin Wang, Hui Shi*, Jin Huang*. Self-Priming DNA Polymerization-Propelled Stochastic Walkers on Magnetic Microbeads for Amplified Detection of miRNA. Anal. Chem. 2022, 95, 9, 4529-4535. (SCI一区)
3. Nuli Xie, Huimin Wang, Xiaoxiao Fu, Jiaoli Wang, Jing Li, Kemin Wang, Jin Huang*. Dual amplification of bio-barcode and auto-cycling primer extension for highly sensitive detection of miRNA. Chem. Commun. 2022, 58, 73, 10221-10224. (SCI一区)
4. Nuli Xie, Mingqiang Li, Yue Wang, Hui Lv, Jiye Shi, Jiang Li, Qian Li, Fei Wang*, Chunhai Fan. Scaling up multi-bit DNA full adder circuits with minimal strand displacement reactions. J. Am. Chem. Soc. 2022, DOI: 10.1021/jacs.2c03258. (SCI一区)
5. Nuli Xie, Shiyuan Liu, Hongmei Fang, Yanjing Yang, Ke Quan, Jing Li, Xiaohai Yang, Kemin Wang, Jin Huang*. Three-dimensional molecular transfer from DNA nanocages to inner gold nanoparticle surfaces. ACS Nano 2019, 13, 4174-4182. (SCI一区)
6. Nuli Xie, Haiyan Wang, Ke Quan, Feng Feng, Jin Huang*, Kemin Wang*. Self-assembled DNA-Based geometric polyhedrons: construction and applications. TrAC-Trends in Anal. Chem. 2020, 126, 115844. (SCI一区)
7. Nuli Xie, Jin Huang*, Xiaohai Yang, Xiaoxiao He, Jianbo Liu, Jiaqi Huang, Hongmei Fang, Kemin Wang*. Scallop-inspired DNA nanomachine: a ratiometric nanothermometer for intracellular temperature sensing. Anal. Chem. 2017, 89, 12115-12122. (SCI一区)
8. Nuli Xie, Jin Huang*, Xiaohai Yang, Yanjing Yang, Ke Quan, Min Ou, Hongmei Fang, Kemin Wang*. Competition-mediated FRET-switching DNA tetrahedron molecular beacon for intracellular molecular detection. ACS Sens. 2016, 12, 1445-1452. (SCI一区)
9. Nuli Xie, Jin Huang*, Xiaohai Yang, Yanjing Yang, Ke Quan, He Wang, Le Ying, Min Ou, Kemin Wang*. A DNA tetrahedron-based molecular beacon for tumor-related mRNA detection in living cells. Chem. Commun. 2016, 52, 2346-2349. (SCI一区)
10. Nuli Xie, Shiyuan Liu, Xiaohai Yang, Xiaoxiao He, Jin Huang*, Kemin Wang*. DNA tetrahedron nanostructures for biological applications: biosensors and drug delivery. Analyst 2017, 142, 3322-3332. (SCI二区)
11. Le Ying #, Nuli Xie#, Yanjing Yang, Xiaohai Yang, Qifeng Zhou, Bincheng Yin, Jin Huang*, Kemin Wang*. A cell-surface-anchored ratiometric i-motif sensor for extracellular pH detection. Chem. Commun. 2016, 52, 7818-7821. (SCI一区)
12. Hongmei Fang#, Nuli Xie#, Min Ou, Jin Huang, Wenshan Li, Qing Wang, Jianbo Liu, Xiaohai Yang*, Kemin Wang*. Detection of nucleic acids in complex samples via magnetic microbead-assisted catalyzed hairpin assembly and “DD-A” FRET. Anal. Chem. 2018, 90, 7164-7170. (SCI一区)
13. Jing Li, Jiaoli Wang, Shiyuan Liu, Nuli Xie, Ke Quan, Yanjing Yang, Xiaohai Yang, Jin Huang*, Kemin Wang*. Amplified FRET nanoflares: an endogenous mRNA‐powered nanomachine for intracellular microRNA imaging. Angew. Chem. Int. Ed. 2020, 132, 20104-20111. (SCI一区)
14. Jesús Mosquera, Yuan Zhao, Hee‐Jeong Jang, Nuli Xie, Chuanlai Xu, Nicholas A. Kotov, Luis M. Liz‐Marzán*. Plamnonic nanoparticles with supramolecular recognition. Adv. Funct. Mater. 2019, 1902082. (SCI一区)
15. Yanjing Yang, Jin Huang, Xiaohai Yang, Ke Quan, He Wang, Le Ying, Nuli Xie, Min Ou, Kemin Wang*. FRET nanoflares for intracellular mRNA detection: avoiding false positive signals and minimizing effects of system fluctuations. J. Am. Chem. Soc. 2015, 137, 8340-8343. (SCI一区)
16. Ke Quan, Jing Li, Jiaoli Wang, Nuli Xie, Qiaomei Wei, Jinlu Tang, Xiaohai Yang, Kemin Wang, Jin Huang*. Dual-microRNA-controlled double-amplified cascaded logic DNA circuits for accurate discrimination of cell subtypes. Chem. Sci. 2019, 10, 1442-1449. (SCI一区)