于霞，副教授，硕士生导师

新颖天然产物发现/结构修饰、生物合成及开发应用课题组成员

（课题组简介链接：http:/info/1097/3767.htm）

电子邮箱: xyu226@csu.edu.cn

教育和工作经历

2003/9–2007/7，北京大学，药学院，学士

2007/9–2009/7，北京大学，药学院，硕士

2009/10–2013/9，马尔堡大学，药学院，博士

2013/12-2014/12，肯塔基大学，药学院，博士后

2015/1-2016/6，加州大学洛杉矶分校，化学与生物分子工程学院，博士后

研究领域和研究方向

1，微生物来源重要次生代谢产物的生物合成研究

2，新颖生物合成酶催化机理研究

3，基于药物靶标的次生代谢产物的基因组挖掘

4，高效生物酶合成法和生物转化法的构建。

代表性论文

[1]X. Yu, F. Liu, Y. Zou, M. Tang, L. Hang, K. N. Houk, and Y. Tang. Biosynthesis of Strained Piperazine Alkaloids: Uncovering the Concise Pathway of Herquline A, Journal of the American Chemical Society, 2016, 138, 13529–13532. (影响因子：13.038)

[2]X. Yu,G. Zocher, X. Xie, M. Liebhold, S. Schütz, T. Stehle, and S.-M. Li. Catalytic mechanism of stereospecific formation ofcis-configured prenylated pyrroloindoline diketopiperazines by indole prenyltransferases, Chemistry & Biology, 2013, 20, 1492-1501.

[3] S. Yin^#,X. Yu^#(并列一作), Q. Wang, X. Liu, and S.-M. Li. Identification of a brevianamide F reverse prenyltransferase BrePT fromAspergillus versicolorwith a broad substrate specificity towards tryptophan-containing cyclic dipeptides, Applied Microbiology and Biotechnology, 2013, 97, 1649-1660.

[4]X. Yu, Y. Liu, X. Xie, X. Zheng, and S.-M. Li. Biochemical characterization of indole prenyltransferases: filling the last gap of prenylation positions by a 5-dimethylallyltryptophansynthase fromAspergillus clavatus, Journal of Biological Chemistry, 2012, 287, 1371-1380.

[5]X. Yu, A. Yang, W. Lin, and S.-M. Li. Friedel–Crafts alkylation on indolocarbazoles catalyzed by two dimethylallyltryptophan synthases fromAspergillus, Tetrahedron Letters, 2012, 53, 6861-6864.

[6]X. Yuand S.-M. Li, Prenyltransferases of the dimethylallyltryptophan synthase superfamily, Methods in Enzymology, 2012, 516, 259-278.

[7]X. Yu, and S.-M. Li. Prenylation of flavonoids by using a dimethylallyltryptophan synthase 7-DMATS fromAspergillus fumigatus, Chembiochem, 2011, 12, 2280-2283.

[8]X. Yu, X. Xie, and S.-M. Li. Substrate promiscuity of secondary metabolite enzymes: prenylation of hydroxynaphthalenes by fungal indole prenyltransferases, Applied Microbiology and Biotechnology, 2011, 92, 737-748.

[9] W. Yin^#,X. Yu^#(并列一作), X. Xie, and S.-M. Li. Preparation of pyrrolo[2,3-b]indoles carrying a ß-configured reverse C3-dimethylallyl moiety by using a recombinant prenyltransferase CdpC3PT, Organic & Biomolecular Chemistry, 2010, 8, 2430-2438.